I sometimes turn the Trifecta tune off just to get used to how slow it was before. Then I turn it back on and smile.
The initial throttle hesitation was slightly present on my car but half a can of seafoam through the intake (and a plug change) fixed that mostly - could have been the butterfly valve or could have been a combination of carbon build up due to GDI. The throttle response now while in Trifecta tune mode is as good as I can expect, it's still not that great with the tune turned off. No issues with engine after 20k miles. Still considering water injection for the hot Florida summers and continuous cleaning of carbon from intake valves.
I hear you on indiscriminately wanting more and more, and how that is a bad philosophy with no set goal of "I'll be happy with this". Trifecta got me to that happy point, any more power for my goals would be pointless for this car. I don't see it as a problem for reliability, nor have I experienced any issues from it other than requiring better band clamps for the increased boost. The GMPP official tune was covered by the factory the warranty so the platform is definitely designed with that power level in mind. The only additional thing I may consider is gutting the cat right after the turbo. Too much heat is retained, and probably some flow issues. The heat appears to be one of the main factors for waterpump issues (probably bakes the seals).
One thing that could be happening is, you have a small boost leak, either from previously mentioned band clamps for the charge pipes/intercooler, or the factory intercooler end tank having a corrosion or ballooning crack. Get an OBD2 reader, and pair it to the Torque app (Android, not sure about iOS) and post your Long Term Fuel Trim (LTFT). Might see an issue if they are far from expected.